![]() ![]() The average case fatality rate was 2.1% (8/389). Consolidated pneumonia was the most frequent clinical presentation (56.9% 224/394). The median age of cases was 12 months (interquartile range: 6-21 months) 56.1% (221/394) of cases were male. Influenza frequency followed a seasonal epidemic pattern (May-July, the lowest average temperature months). Of 14,044 patients, 37.7% (5290) had FA- or RT-PCR-confirmed samples that identified influenza in 2.8% (394/14,044 91.4% influenza A, 8.6% influenza B) of cases. In a prospective, cross-sectional study, patients admitted for aLRTI, between 20, were tested for respiratory syncytial virus, adenovirus, influenza, or parainfluenza, and confirmed by fluorescent antibody (FA) or real-time polymerase chain reaction (RT-PCR) assay of nasopharyngeal aspirates. This study aimed to describe the clinical and epidemiologic patterns and infection factors associated with influenza, and compare case features of influenza A and B. Influenza is an important cause of acute lower respiratory tract infection (aLRTI), hospitalization, and mortality in children. It is thus suggested that more effort be focused towards implementing the current global recommendations for the prevention of RSV-associated LRI, particularly in infants. RSV has remained a common cause of severe ALRI in infants, especially during the rainy months in Nigeria. These findings were largely consistent with those of earlier reports. The proportion of infants in the RSV-positive group was significantly higher than that in the RSV-negative group (82.9% vs 54.4% p=0.002). ![]() The prevalence of RSV infection was 34.2% and its peak was in the rainy months. Relevant data were obtained and an antigen detection assay was used for viral studies. We performed a descriptive cross-sectional study conducted over 1 y of 120 children, ages 2-59 months, diagnosed with ALRI. The current study thus set out to determine the prevalence of RSV infection among hospitalized children <5 y of age and describe the related social determinants. ![]() With recent advances in RSV preventive strategy, arises the need for a recent appraisal of RSV infection in children with severe ALRI. However, Nigerian reports on severe childhood RSV ALRIs are rare and most reports are old. RSV infection displayed a seasonal pattern and was associated with infants younger than 3 months old with bronchiolitis and hypoxemia at the time of admission.Īcute lower respiratory tract infections (ALRIs) especially severe ALRIs, constitute a global high burden of morbidity and mortality in children <5 y of age and respiratory syncytial virus (RSV) has been documented to a play a major aetiological role. Independent predictors of RSV infection were age <3 months old (OR: 2.8, p < 0.01),clinical presentation of bronchiolitis (OR: 1.54, p < 0.01), and hypoxemia at the time of admission (OR: 1.84, p < 0.01). The most common comorbidities were chronic respiratory disease (74%), congenital heart disease (14%), and chronic neurological disease (10.2%).Complications occurred in 25%of cases. Comorbidities were observed in 41.6% of cases. RSV accounted for 81.8% of cases (3924/4798) with no significant annual variations (71.2- 88.1) and with an epidemic seasonal pattern(May through July) RSV was followed by influenza (7.6%), parainfluenza (5.9%), and adenovirus (4.7%).The median age of patients with RSV rescue (3924) was 7 months old (0- 214 months old), while 74.2% were younger than 1 year old, 43.1% were younger than 6 months old, 56.5% were males and the most common clinical presentation was bronchiolitis (60.7%). The virological diagnosis of RSV, adenovirus, influenza and parainfluenza was performed by indirect immunofluorescence using nasopharyngeal aspirates.Ī total of 12,555 children were included, 38.2% (4798) had virus rescued from samples. Prospective, cohort study on patients hospitalized due to acute lower respiratory tract infection at Hospital de Niños Ricardo Gutiérrez between March and November throughout the 2000-2013 period. Respiratory syncytial virus (RSV) is the major causative organism associated with acute lower respiratory tract infections in children.The objective of this study was to describe the clinical and epidemiological pattern of RSV and identify risk factors for RSV infection. ![]()
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